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Orioles at Guardians Prediction: Odds, expert picks, starting pitchers, betting trends and stats for July 23

It’s Wednesday, July 23 and the Orioles (44-56) are in Cleveland to take on the Guardians (50-50). Zach Eflin is slated to take the mound for Baltimore against Slade Cecconi for Cleveland.

The Guardians took the second of the four-game series with the Orioles, 6-3, a day after winning the opener, 10-5. Cleveland is on a three-game winning streak, 4-1 in the past five and 8-2 over the last 10, so the Guardians are getting hot, while the O’s are 1-6 in the last seven.

Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Orioles at Guardians

Date: Wednesday, July 23, 2025
Time: 6:40PM EST
Site: Progressive Field
City: Cleveland, OH
Network/Streaming: MASN2, CLEG

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Odds for the Orioles at the Guardians

The latest odds as of Wednesday:

Moneyline: Orioles (+109), Guardians (-129)
Spread: Guardians -1.5
Total: 8.0 runs

Probable starting pitchers for Orioles at Guardians

Pitching matchup for July 23, 2025: Zach Eflin vs. Slade Cecconi
- Orioles: Zach Eflin, (6-5, 5.95 ERA)
  Last outing: 36.00 ERA, 4 Earned Runs Allowed, 5 Hits Allowed, 0 Walks, and 0 Strikeouts
- Guardians: Slade Cecconi, (5-4, 3.84 ERA)
  Last outing: 6.48 ERA, 6 Earned Runs Allowed, 8 Hits Allowed, 0 Walks, and 2 Strikeouts

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Expert picks & predictions for tonight’s game between the Orioles and the Guardians

Rotoworld Best Bet

Vaughn Dalzell (@VmoneySports) likes the Guardians to reach 80 wins:

“In the first 24 games of the 67 one second-half of the schedule are the Athletics, Orioles, Royals, Rockies, Twins, Mets, White Sox, and Marlins -- beautiful! Cleveland took the series against the A’s, 2-1 and beat the O’s in the opener— so far so good.

The Guardians have the easiest strength of schedule remaining in the MLB and need a 34-33 record over the second half to secure 80-plus wins, which I believe is more than possible.”

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday’s game between the Orioles and the Guardians:

Moneyline: NBC Sports Bet is recommending a play on the Cleveland Guardians on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Baltimore Orioles at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Top betting trends & insights to know ahead of Orioles at Guardians

Eflin hasn’t started since June 28
The Guardians are 4-2 in the past six with Cecconi and 2-0 in the last two
The Guardians have won 8 of their last 10 games
The Orioles’ last 5 road games at the Guardians have gone over the expected total
Baltimore have lost 4 of their last 6 games by at least 5 runs

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

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